The village of Pefkoi is built in altitude of about 420 metres on the south slope of mountains that have the name of their tallest mountain top, called “Romanati”. The land is rocky at its biggest part and forms a scenery landscape of unique attractiveness.
Above the village is the mountain of Afendis-Stavros ("Stauromenos") in the top of which the homonym tabernacle has been built. South of the village, a mountainous landscape mainly consisting of soil allows the growth of olive trees, fruit-bearing trees and gardening. Big part of the landscape is covered by forests of pines, wild locust trees, olives, bushes and many other forestall plants. Travelling southern the land is more level allowing the growth of vines and greenhouse products.
The region of Pefkoi has coverage of forty thousand acres, is located 35 kilometres south-west of the Sitia town, and 30 kilometres east of Ierapetra. It borders with the village of Krya from the north, while from the south it has the Livykon sea with the scenery beaches of Analypsis, Maky Gialos, Diaskari and Lagkadas in a distance of 7 kilometres. On the west Pefkoi borders with Agios Stefanos village and with Lithines village from the east as well as the Municipality of Maky Gialos.